Welcome to the E-Signal website –‘ECM-signaling Laboratory’. We seek at answering fundamental questions in gland development and cancer biology.
How do ECM-signals go to the cell nucleus and influence gene expression programs in morphogenesis and cancer?
How does the microenvironment regulate tissue development and how aspects of this regulation can be affected causing appearance of tumors? What determines architecture and size of branched organs and how these features are lost in cancer progression?
The answers for these questions are relevant and will help understand fundamental mechanisms of the development of biological systems, solve paradigms for creating new tools for regenerative medicine, tissue engineering, diagnostic, prognostic and treatment of cancer.